High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.

Introducing premature visual experience by opening the closed eyelids early in ferrets caused many cells in the primary visual cortex to mature improperly.

Imperial College London and the University of Sheffield have signed up to eLife’s uncapped scheme in support of a more open, equitable and sustainable science publishing system.

The dorsal vagal complex is a highly intricate structure composed of distinct transcriptional classes of glial and neuronal cells, exhibiting many similarities but also notable differences between ...

Machine learning with whole-cell patch-clamp and local field potential recordings reveals that synaptic responses from five mossy cells, despite their limited population, can significantly reconstruct ...

Manipulating the neuronal pathway responsible for the hypoxic stress response in the worm C. elegans leads to an increase in lifespan.

This important study identifies a putative iron and zinc transporter in the plasma membrane of the obligate intracellular pathogen, Toxoplasma gondii. Using an array of different approaches, the ...

This valuable study identifies a brown adipose tissue-specific heat shock factor 1-alcohol dehydrogenase 5 (ADH5) molecular cascade as a regulator of systemic aging, showing that ADH5 deficiency ...

Review of the emerging understanding of trained immunity in the skin and how infection-driven cellular processes induce long-lasting immune adaptation and modulate skin barrier integrity.

Individual retinal ganglion cells are singularly activated in the living primate retina via an adaptive optics scanning light ophthalmoscope.

Rapid, combined and personalized non-invasive stimulation of the precuneus improves associative memory, enhances local gamma expression, and strengthens precuneus–hippocampal connectivity.

This paper presents important new findings about the impact of the TAK-003 vaccine against dengue based on a convincing reanalysis of trial data. The results corroborate those of the original trial ...