Researchers have shown that 5mC is associated with genes turned "off" while 5hmC, mediated by TET proteins, is associated with gene expression turned "on." This "on/off" epigenetic system gives ...

1). In the 'off' state, the Lac inhibitor represses the lac operon, which prevents expression of the Tet repressor and the target gene. Additionally, a short hairpin RNA (shRNA) against the target ...