NK cells contribute to the rejection of skin allografts by directly killing donor cells (via detection of missing self-MHC class I molecules) or indirectly through antibody-dependent cellular ...

Once there, I found that Snell had proposed that hybrid resistance was controlled by MHC molecules themselves, such that self MHC molecules on host cells and tumor cells would interact ...

In contrast to the latter hypothesis, our results underline the similarity between allorecognition and the recognition of foreign peptides bound to self-MHC molecules. Our data also indicate that ...

"However, when the MHC-II is missing a crucial piece called the invariant chain (Ii), it can present larger, misfolded self-antigens, called neoself-antigens, to T cells." Given that ...

allergens and even to self antigens. T cells use the T cell antigen-receptor (TCR) to recognize their antigens, which are often in the form of peptides bound to major histocompatibility complex ...

Finally, several studies demonstrate that NK cells, activated due to missing self-MHC class I molecules on allogeneic cells, are involved in allogeneic skin graft rejection via direct killing of ...