The ‘Molecular Devils’ That Cause the Most Fatal Diseases Ever Known CJD and similar brain diseases are caused by a misfolded version of the naturally occurring prion protein. When these rogue ...

It is the original example of a group of diseases, known as the "transmissible spongiform encephalopathies" (TSE), sometimes known as the "prion" diseases. The diseases include Creutzfeldt Jakob ...

Until now, most prion research explored brain tissue--the end point of infection. But a few investigators are seeking the site where prions pathogenesis begins. And their work is converging on a ...

The National Prion Disease Pathology Surveillance Center (NPDPSC) is the only Center of its kind in the U.S., which coordinates autopsies and neuropathologic examinations of suspected prion disease ...

Prions are best described as misfolded proteins with an ability to transmit their misfolded shape onto normal variants of the same protein. Let's dive into the many fatal neurodegenerative ...

In TSEs the normal cellular prion protein (PrP C) is transformed into an infectious disease-associated isoform, PrP Sc — a potential target for immunotherapy. In the March 6 Nature, Anthony R. White ...

A system for the rapid amplification of misfolded prion oligomers provides new evidence supporting the prion hypothesis and may offer a powerful diagnostic tool. You have full access to this ...

A mad cow’s milk may contain prion proteins and the disease might be transmitted from the mad cow to humans who happen to drink its milk Mad Cow Disease, also known as Bovine Spongiform ...

The characteristic diagnostic signs of prion disease in humans and animals, such as changes in behavior and mobility, result from advanced neurodegeneration for which there is currently no cure.