Cytoskeletal remodelling proteins such as p21-activated kinase 1 (PAK1) have been predicted to regulate mitosis by activating Aurora A, although it has been unclear how. In the Journal of Cell ...

MetasTx has created an anti-metastasis platform based around the small molecule IPA-3, a highly selective allosteric inhibitor of group 1 p21-activated kinases (PAK1). This is a family of ...