Researchers found that the loss of p53 function led to the secretion of IL-34 directly. But the blockade of IL-34 restrained ...

Moreover, P53 knockout in mice led to downregulated expression of apoptosis signaling in the liver. Mechanistically, P53 may regulate apoptosis by transcriptionally activating the expression of ...

Loss of normal p53 function has been associated with resistance ... specific since we found that the cells in organs such as liver, lung, muscle, bone marrow, and intestinal crypts were not ...

Mindrank Therapeutics (Suzhou) New Drug Research & Development Co. Ltd. has disclosed cellular tumor antigen p53 (TP53) (Y220C mutant) stabilizers reported to be useful for the treatment of cancer.

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007;445(7128):656-60. 4. Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, Whittaker CA, ...