burgdorferi does not use thiamin as a cofactor and instead relies on lactate dehydrogenase (BbLDH) to convert pyruvate to lactate to balance the NADH/NAD+ ratio, which has not been reported in any ...

Proliferating cells, in particular tumor cells, express a dimeric isoenzyme of pyruvate kinase, termed Tumor M2 pyruvate kinase. In the last few years, much attention has been paid to this novel ...