Pancreatic cancer is a leading cause of cancer-related death, with a five-year survival rate of 13%. The high mortality is ...

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Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal ... with a high incidence of grade 3 hand–foot syndrome/skin reaction (45%). Sorafenib-plus-paclitaxel demonstrated ...

We are a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers. Our company was ...

One target for such inhibition, the p38 mitogen-activated protein kinase (MAPK) signaling cascade, has a role in inflammation by mediating the cellular response to stress, pathogens, and cytokines.