Recent research sheds light on how changes in the chemical structure of a protein called Interleukin-6 affect lung cancer’s ...

SOCS1 stands for "suppressor of cytokine signalling 1," an endogenous factor that keeps cytokine activity mediated through ...

A recent study published by the lab in Nature Communications [2024; PMID: 38355560] sheds light on this aspect by elucidating the role of the IL6/JAK/STAT3 signaling pathway in driving bladder cancer ...

The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer. Amara CS, Kami Reddy KR, Yuntao Y, Chan YS, Piyarathna DWB, Dobrolecki LE, Shih DJH, Shi Z, Xu J, ...

The study suggests that disturbances in the JAK-STAT signalling pathway, an important communication pathway in the body, may contribute to this side effect. “In the study, we uncover the ...

They found a protein called STAT3, key to a cell signaling pathway called JAK, at the center of activity in the seizure-affected mouse brains. "When we did a similar analysis of data from brain ...