The focus is to to characterize the neuroinflammatory response to surgery and morphine in young and aged rats; and to determine the roles of HMGB1 and microglia in mediating POCD. The guiding ...

First, peripheral levels of RAGE ligands, such as S100/calgranulins, AGEs and HMGB1, can be reduced, which can ultimately attenuate vascular inflammation and increase integrity of the BBB.