Enliven Therapeutics is a clinical-stage concern that has two candidates in its pipeline targeting oncology indications.

Researchers from the Wellcome Sanger Institute and their collaborators used whole genome sequencing to study when BCR::ABL1—an abnormal fusion of the different genes called BCR and ABL1 ...

In this study, we tried to determine how quickly CML develops after BCR::ABL1 fusion, how growth rates might vary between individuals, and how tumour dynamics influence the clinical features of ...

Researchers have found that the clinical application of BCR::ABL1 digital PCR can reliably quantify stable deep molecular remission of chronic myeloid leukemia (CML), which will help to determine ...

Dr. Westerweel concludes, "Digital PCR for BCR::ABL is a valuable and reliable tool to aid clinical decision making in CML." More information: Camille Kockerols et al, BCR::ABL1 Deep Molecular ...

Researchers have found that the clinical application of BCR::ABL1 digital PCR can reliably quantify stable deep molecular remission of chronic myeloid leukemia (CML), which will help to determine ...

Researchers have explored the evolution of the genetic change that causes chronic myeloid leukaemia and show its ability to drive the disease.

Commenting on the findings of the study, Dr. Westerweel says, "BCR::ABL1 digital PCR was found to accurately quantify BCR::ABL1 around the level of 0.0023% on the International Scale, which is the ...