Isolere Bio by Donaldson, an innovative bioprocessing technology provider, proudly announces the availability of its manufacturing-grade IsoTag™ AAV reagent for the purification of Adeno-associated ...

The team tested the impact on eight novel helper plasmids with different deletions in the E2 and E4 genes on four rAAV serotypes. They discovered that some deletions affected productivity, reducing ...

AAV is a useful vector for delivering genes; however, the size of the gene that can be carried is limited. Therefore, Dr. Kamiya and his team constructed a base editing tool (SaCas9-NNG-ABE8e ...

This in silico approach aims to increase the fitness of clinical adeno-associated virus (AAV) capsids to make gene therapies more economically viable for patients. Developing AAV capsids with ...

With such a small sample size and short follow-up time ... DOI: 10.1056/NEJMoa2410597 Johnny Mahlangu, Could Lentivirus Overcome the AAV Gene-Therapy Challenges in Hemophilia A?, ...

While this technique is effective, it is limited on manufacturability and modularity, with constraints such as the size and presentation of the peptide. Coave's ALIGATER platform enables the direct ...