Their findings suggest that 5′ overhang–containing dsRNA is a new, previously uncharacterized RNA intermediate in the RNA silencing pathway. siRNA pathways may generate 5′ overhang ...
resulting in the generation of an siRNA, a 21–23-nucleotide (nt) RNA duplex, composed of a 19-mer sequence with symmetric 2–3-nt 3′ overhangs. The siRNA associates with cellular proteins to ...
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