They found linoleic acid can activate mTORC1, which is considered the "control centre" in cells which decides whether they grow, divide or make proteins. In cases of aggressive breast cancer ...

They looked at the ability of omega-6 fatty acids—particularly linoleic acid, the dominant one in the Western diet—to drive an important, nutrient-sensing growth pathway called the mTORC1 pathway.

They identified the mechanistic target of rapamycin complex 1 (mTORC1) pathway as a highly used system. Then the researchers developed a conditional mutant mouse model with a deleted upstream mTORC1 ...

They looked at the ability of omega-6 fatty acids—particularly linoleic acid, the dominant one in the Western diet—to drive an important, nutrient-sensing growth pathway called the mTORC1 pathway. A ...

A major player in this balancing act is a cellular signaling network called mTORC1. It acts like a sensor and regulator, helping cells grow when nutrients are available. This pathway is especially ...

The interaction leads to the activation of the mTORC1 pathway, which regulates cell growth and metabolism. “This discovery helps clarify the relationship between dietary fats and cancer ...