They looked at the ability of omega-6 fatty acids—particularly linoleic acid, the dominant one in the Western diet—to drive an important, nutrient-sensing growth pathway called the mTORC1 pathway.

Their research revealed linoleic acid can activate mTORC1 — the 'control center' in cells that decides whether they grow, divide or make proteins. In aggressive breast cancer, excess linoleic ...

They found linoleic acid can activate mTORC1, which is considered the "control centre" in cells which decides whether they grow, divide or make proteins. In cases of aggressive breast cancer ...

They identified the mechanistic target of rapamycin complex 1 (mTORC1) pathway as a highly used system. Then the researchers developed a conditional mutant mouse model with a deleted upstream mTORC1 ...

They looked at the ability of omega-6 fatty acids—particularly linoleic acid, the dominant one in the Western diet—to drive an important, nutrient-sensing growth pathway called the mTORC1 pathway. A ...

A major player in this balancing act is a cellular signaling network called mTORC1. It acts like a sensor and regulator, helping cells grow when nutrients are available. This pathway is especially ...

ARV-393 is Arvinas’ investigational PROteolysis TArgeting Chimera (PROTAC) degrader targeting the B-cell lymphoma 6 protein (BCL6), a transcriptional repressor and major driver of B-cell lymphomas.

The company will also highlight preclinical study of ARV-393, an investigational PROTAC BCL6 degrader, in combination with standard of care therapies. The poster highlights the potential for ARV-393 ...