The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

The reduced activity of mTOR during fasting subsequently leads ... of the eukaryotic translation initiation factor 4E (P-eIF4E). P-eIF4E plays a crucial role in regulating the translation of ...