Blagosklonny goes on to write that even though rapamycin may reverse some manifestations of aging, it is more effective at ...

WAYNE, PA — Palvella Therapeutics, Inc. (Nasdaq: PVLA), a biopharmaceutical company focused on developing treatments for rare ...

The drug blocks the activity of a protein known as mammalian target of rapamycin (mTOR), which promotes proliferation through the activation of proteins such as S6 kinase. Although the mTOR ...

The authors discuss several major pathways involved in breast cancer, including PI3K/Akt/mTOR, RAS/RAF/MEK/ERK, HER2, Wnt/β-catenin, Notch, NF-κB, and the DNA damage response (DDR). These ...

In the area of growth control, our recent work is focused on the mTOR pathway that controls multiple aspects of cell growth and homeostasis. Our work on genomic integrity ranges from the Fanconi ...