In eukaryotic cells, mRNA decay is catalyzed by two major pathways, and both can be initiated by deadenylation of the polyadenylated (poly-A) tail. After decapping, 5’ to 3’ RNA degradation is ...

More information: You Zhou et al, m6A sites in the coding region trigger translation-dependent mRNA decay, Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.10.033 ...

In eukaryotes, the process of mRNA decay generally involves loss of the 3′ poly(A) tail and removal of the cap by a decapping enzyme (Dcp2). The body of the mRNA is then degraded from the 5 ...

It also demonstrates for the first time the link between mRNA decay regulation and brain size control. Additionally, it ...

The yeast RGG motif-containing RNA binding protein Scd6 and its human ortholog LSM14A regulate the translation of specific ...

Nonsense-mediated mRNA decay (NMD) denotes the remarkable cellular surveillance system in eukaryotic cells that recognizes and eliminates mRNA encoding nonsense codons within their protein-coding ...

Lawmakers in Iowa, Montana, Idaho, Texas and Kentucky introduced bills that would ban or restrict vaccines that use messenger RNA, or mRNA, technology — despite its immense potential for ...

Mugridge JS, Coller J, Gross JD. Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay. Nature Structural & Molecular Biology (2018), 25(12), 1077-1085. Mugridge JS, ...

Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics.