Both SGS3 and a viral suppressor of RNA silencing have now been shown to selectively bind 5′ overhang–containing dsRNA, implicating this RNA as a new intermediate in the RNA silencing pathway.

RNA interference (RNAi)—the use of a double-stranded RNA (dsRNA) to trigger the destruction of a corresponding gene’s messenger RNA—is a popular method for ascertaining gene function. But for ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

Scientists develop RNA-based technology to combat plant viruses, enhancing crop immunity and reducing losses worldwide.

Double-stranded RNA can be introduced experimentally to silence genes of interest. In plants, silencing can be triggered, for example, by engineering RNA viruses. In worms, silencing can be ...

The scientist who discovered hybridization and the "other" double helix describes what it meant to biology. By Alexander Rich Fifty-two years ago I was venturing to the basement of Cal Tech chemistry ...

A new study conducted by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has uncovered a key mechanism behind lenalidomide resistance ...

ADAR1 inhibits lenalidomide's activity by editing double-stranded RNA (dsRNA), thus hindering the immune response and reducing the effectiveness of the drug in combating MM growth and proliferation.

Developed to help fight the virus by directing the plant’s natural defenses in the right direction the new molecules, known as efficient double-stranded RNA (edsRNA), demonstrate a broad ...

There’s a new villain in the hive. On his radio program, "CBS Eye on the World," John Batchelor and I unpacked the real threat to honeybees, discussed a new remedy for it, and explained why treating ...