The drug is designed to block the CCR4 receptor protein ... antitumor effects in patients with EBV-positive gastric cancer.

Shanghai Pharmaceuticals Holding Co. Ltd. has identified C-C chemokine receptor type 4 (CCR4) antagonists reported to be useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, ...

CCR4 is expressed by several immune cells such ... The therapy is being tested alone and in combination with MSD’s blockbuster cancer treatment Keytruda (pembrolizumab). Earlier this year ...

Patients with cancer have detectable numbers of T cells ... which express the CCL22 receptor CCR4. An antibody against CCL22 prevented trafficking of regulatory T cells to human ovarian tumours ...