Small-molecule approaches that suppress (or reverse) hypertrophy to the extent observed here are uncommon, suggesting that the underlying mechanisms linked to modulation of PDE5A, cGMP and/or PKG ...

One key pathway is the soluble guanylyl cyclase–cyclic GMP–protein kinase G system. If it is produced in excess, or if a cell is under conditions of oxidative stress, NO becomes noxious and ma ...

Objective: Given the therapeutic and non-therapeutic use of the tadalafil, (phosphodiesterase-5 inhibitor, PDE-5i), we examined its effects on anaerobic performance indices. Methods: In total, 12 well ...