The proto-oncogene c-MYC encodes a transcription factor that is implicated in various cellular processes ? cell growth, proliferation, loss of differentiation and apoptosis. c-MYC activates a ...

c-MYC has a pivotal function in growth control, differentiation and apoptosis, and its abnormal expression is associated with many tumors. Overexpression of c-MYC sensitizes cells to apoptosis by ...

Medulloblastomas are one of the most common childhood brain cancers. University of Michigan researchers have now identified a ...

Led by University of Michigan researchers, a study in Cancer Cell identified a new target for Group-3 medulloblastomas. The results help identify new therapeutic avenues for treating these deadly ...

Ryo Miyake) in the University of Tokyo that the efficacy of polymeric nano-micelles with different drug activation profile depends on the expression level of c-Myc, one of the major proto-oncogene ...

Breast cancer is the most frequent malignancy among women worldwide, and all subtypes of breast cancer involve upregulation of the c-Myc gene, making it a compelling therapeutic target. G-rich regions ...

Pioneered by Dr. Chidiebere Awah MD, PhD, our CEO and Principal Investigator, UTRxM1-18 targets oncogenic c-MYC by recognizing specific motifs and switching the ribosome machinery from a ...

Preliminary safety and activity of perioperative triplet chemotherapy plus bevacizumab (bev) in patients with borderline resectable colorectal cancer liver metastases (CLM). Final phase II trial ...

and follicular hyperplasia (right); there is bright nuclear staining of MYC protein in Burkitt's lymphoma cells, compared with < 5% of benign germinal center B cells stained for MYC (right). (B) MYC ...

Medulloblastomas are one of the most common childhood brain cancers. Group-3 medulloblastomas are particularly aggressive and incurable, contributing to childhood cancer deaths. Led by University of ...

Pioneered by Dr. Chidiebere Awah MD, PhD, our CEO and Principal Investigator, UTRxM1-18 targets oncogenic c-MYC by recognizing specific motifs and switching the ribosome machinery from a translational ...