Additionally, detection of both anti-MHC class I and class II antibodies was problematic. The predominant problem underlying class distinction arises from the distribution of HLA antigens.

The team then engineered KG2032 CAR T cells without the reactive HLA-DRB1 allele to test this finding. The KG2032 CAR T cells displayed strong and specific anti-AML effects in vitro with cell ...

A multi-institutional team developed a chimeric antigen receptor (CAR) T cell-based strategy for specifically targeting AML cells in patients who relapsed following other treatments. The team ...

I am involved in the immunological part of the project. In this role, I have helped develop the tools to identify the most immunogenic HLA mismatches for inducing a strong anti-tumour response. Our ...

as well as the native HLA molecules. In essence, the anti-HLA antibodies can bind to regions of bead-coupled HLA molecules that are normally not accessible if they are masked by ß2-microglobulin ...