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Study reveals key mechanism driving atherosclerosis in Hutchinson-Gilford progeria syndrome
In the study, the researchers identify the activation of the YAP/TAZ pathway in endothelial cells as a major contributor to the development of atherosclerosis in HGPS. The discovery, published in ...
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Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease
The HIPPO pathway controls organ size by regulating cell proliferation and apoptosis, acting through its core components MST1/2, LATS1/2, and downstream effectors YAP and TAZ. In the liver ...
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Fig. 2: YAP/TAZ Hyperactivation in Intestinal Stromal Cells Induces Lacteal Sprouting and Branching (IMAGE)
Lacteals (in green) are shown in normal conditions (left) and with YAP/TAZ hyperactivation (right). Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to ...