Wnt ligands are known to be strong drivers of fibrotic mechanisms and are highly expressed in diseases such as IPF. Wnt ligands regulate multiple aspects of disease biology so porcupine inhibition ...

In the canonical pathway, Wnt ligands bind to Frizzled receptors, stabilizing β-catenin, which accumulates in the cytoplasm ...

Finally, pathways such as Wnt signaling are very complex and involve a number of different ligands, receptors and endogenous antagonists and the activation of distinct intracellular signaling ...

The NOTCH family includes four receptors (NOTCH1-4) and interacts with ligands like Delta-like (DLL ... with other pathways like TGF-β, WNT, and hypoxia signaling. The canonical NOTCH pathway ...