while sFRPs complex with Fz receptors to prevent Wnt ligand binding. The illustration was inspired by and created in BioRender. Credit must be given to the creator. Only noncommercial uses of the ...

We know today that Wnt and a handful of other signalling systems (Notch, Hedgehog, TGFβ (transforming growth factor-β)–BMP (bone morphogenetic protein) and receptor tyrosine kinases ...

Porcupine inhibition is a novel anti-fibrotic approach that suppresses Wnt ligand secretion from pro-fibrotic cells. Wnt ligands are known to be strong drivers of fibrotic mechanisms and are ...