(A) Relative CTNNB1 mRNA level in normal and pancreatic adenocarcinoma cell lines. (B) The correlation between relative IARS2 mRNA transcription level and CTNNB1 mRNA transcription level.

Figure 2: Human APC and CTNNB1 mutations are associated with carcinogenesis. Figure 3: Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so ...

Their most recent research, published in EMBO Molecular Medicine, provides the first evidence that an efficacious drug treatment can be developed for this disorder, called CTNNB1 syndrome ...