Figure 2: Human APC and CTNNB1 mutations are associated with carcinogenesis. Figure 3: Cancer therapeutics that target components of the canonical Wnt pathway. Recent studies suggest that so ...

driven by Wnt signaling through LRP5/6 and β-catenin, which interact with APC, CKIα, and TCF/LEF. The NF-κB pathway is a central signaling network regulating inflammation, immune responses ...

Figure 6: The mechanism by which WNTs prevent the GSK3-catalysed phosphorylation of axin, APC and β-catenin ... signalling without triggering the WNT signalling pathway. If such drugs can ...