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A variety of methods to manipulate Ad5 interactions with host proteins and alter the vector tropism are under investigation. These include genetic manipulation of capsid proteins, polymer coating ...

Recently, several techniques have been developed to enhance vector tropism, such as genetically inserting peptides on the AAV capsid to modify their interactions with known cell receptors. While this ...

Next, they loaded this base editing tool onto AAV-Sia6e, which has high infection tropism for inner ear cells and developed an all-in-one AAV vector for inner ear genome editing. Genome editing ...

Firstly, the viral vector. The company uses a non-replicating ... well known for high specificity for cardiac muscle, and this ‘tropism’ is a key ingredient for successful transfection.

In addition to their improved tropism for the target tissues ... research and development and its world-class expertise in AAV-vector engineering and neurobiology, the company is actively engaged ...