The effects of serum starvation and vascular endothelial growth factor (VEGF) stimulation on the Notch signalling pathway in brain microvascular endothelial cells (MECs) and mouse embryonic stem (mES) ...

Akeso Pharmaceuticals and Summit Therapeutics have reported that their PD-1/VEGF bispecific antibody has met the primary ...

However, tumor vasculature is abnormal, chaotic and leaky due to the high production of angiogenic factors such as VEGF. In tumors, Dll4/Notch signaling appears to dampen (much like a resistor in ...

The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be ...

Today, angiogenesis is the central focus in the pathogenesis of this disease, with VEGF identified as a major mediator of this process. These advances have opened the door for targeted anti-VEGF ...

The drug also showed potential efficacy in patients who failed to optimally respond to anti-VEGF treatment. Results of a phase IIb trial comparing UBX1325 to anti-VEGF therapy are expected later ...