The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be ...

Today, angiogenesis is the central focus in the pathogenesis of this disease, with VEGF identified as a major mediator of this process. These advances have opened the door for targeted anti-VEGF ...

These TAMs are polarized toward the M2 phenotype by CSF-1 and CCL2, and produce factors that promote invasion and suppress adaptive immunity, promoting tumor growth and metastasis. Expert Rev Mol ...