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The ability of tumours to induce new blood-vessel formation has been a major focus of cancer research over the past few decades, and vascular endothelial growth factor (VEGF) is now known to be ...
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The biological effects of VEGF are extremely dose-dependent. Loss of even a single allele results in fatal vascular defects in the embryo 2,3, whereas insufficient levels of VEGF or its VEGF 164 ...
Today, angiogenesis is the central focus in the pathogenesis of this disease, with VEGF identified as a major mediator of this process. These advances have opened the door for targeted anti-VEGF ...