The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification. The molecular mechanism that mediates this pH ...

V-ATPase works inside eukaryotic cells to acidify their components, and transport protons across plasma membranes. When Oxr1 and Ncoa7 function was inhibited, ...

Our team saw that V-ATPase interacts with several components of the synaptic vesicle, which contains many proteins and lipids that are involved in neurotransmitter release.

V-161, a novel compound targeting the Na +-V-ATPase enzyme in vancomycin-resistant Enterococcus faecium (VRE), significantly reduces bacterial growth and colonization.. This breakthrough offers ...

Now that we have discovered that V-ATPase interacts with synaptophysin in synaptic vesicles, we are working with Dr. Lu-Yang Wang, a Senior Scientist in the Neurosciences & Mental Health program ...

The V-ATPase enzyme is an important drug target because it plays critical roles in cancer, cancer metastasis, and several other life-threatening diseases. Thus, the V-ATPase is a lucrative target for ...

Further, effective TFEB/V-ATPase signaling is critical for lysosomal homeostasis and immune regulation in the context of Tau/NFT pathology. This will be testing using novel mouse models and ...

This restored v-ATPase assembly and lysosomal acidification in the DS cells, and even improved lysosomal function in control cells. β-CTF Disables v-ATPase. Untreated Down’s cells (left) have low ...

V-161, a novel compound targeting the Na+ -V-ATPase enzyme in vancomycin-resistant Enterococcus faecium (VRE), significantly reduces bacterial growth and colonization.

In efforts to design microtubule polymerization inhibitors with the ability to induce immunogenic cell death (ICD), investigators from China Pharmaceutical University have discovered novel ...

In contrast, depletion of FBXO9 reduced ATP6V1A ubiquitination, resulting in increased V-ATPase assembly and vesicular acidification, thus promoting pro-metastatic Wnt signaling and metastasis of lung ...