Uricase degrades relatively insoluble uric acid to the more soluble compound allantoin. Urate reabsorption by urate transporter-1 is partly suppressed at the proximal tubule lumen membrane by the ...

When there is too much of this compound in your body, urate crystals can form in your ... In general, however, they affect uric acid reabsorption and/or decrease uric acid secretion.