An experimental drug could be game-changing for millions of Americans with a higher genetic risk of cardiovascular disease.

The double-stranded RNA is processed by an RNase III family enzyme Dicer, resulting in the generation of an siRNA, a 21–23-nucleotide (nt) RNA duplex, composed of a 19-mer sequence with ...

Reporting in Nature, Kumar and colleagues have now developed a method to target small-interfering RNA (siRNA) to the CNS, providing a safe and non-invasive approach for the delivery of this new ...

In SNALPs, the backbone-modified siRNA is encapsulated within a closed ... by both constitutive and inducible pathways in a cell type-specific manner using CME and macropinocytosis (Figure 2C).