Tumors are held together by a structure called the extracellular matrix (ECM) that acts like the scaffolding around a ...

Adhesive Interactions Influencing Metastases Integrins are the major extracellular matrix (ECM) receptors, and integrin-mediated adhesive interactions between tumor cells and the components of ...

CAFs Impact ECM and tumor growth: CAFs secrete MMPs to degrade ECM, releasing growth factors for cancer cells. ECM changes counteract CAFs and tumor cells: (a) Hard ECM triggers Twist release from ...

research published in Nature Communications* on the 14th of February details how the structure of the extracellular matrix (the ECM) acts as a physical roadmap, which actively guides cancer cells ...

face limitations such as minimal survival extension and ECM-induced drug delivery failures. Penetrium's unique strategy overcomes these barriers by targeting the tumor microenvironment itself ...