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Valproic Acid Decreases Urothelial Cancer Cell Proliferation and Induces Thrombospondin-1 Expression
Second, we demonstrated that valproate increased TSP1 production, evidenced by increased mRNA expression. The UMUC-3 cell line also displayed profound morphological changes with valproate.
Valproic Acid Decreases Urothelial Cancer Cell Proliferation and Induces Thrombospondin-1 Expression
In conclusion, we confirm decreased proliferation of bladder cancer cells by treatment with HDAC inhibitors and show increased expression of TSP1 in bladder cancer by this class of drug.
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