It all comes down to a special protein in the body called titin. Titin is responsible for making muscle stretchy and bendy. But a mutation in the TTN gene (which makes the titin protein ...

More than half of the titin molecule is attached to the thick filament, where it might control the exact assembly of myosin and other filament components. Between the end of the thick filament and ...

TTN, the gene encoding the sarcomere protein titin, has been insufficiently analyzed for cardiomyopathy mutations because of its enormous size. We analyzed TTN in 312 subjects with dilated ...

The model is based on earlier work by the same team, which found that a component of muscle called titin is responsible for generating the chemical signals which affect muscle growth. The results ...

A new study has identified genetic mutations that cause the heart condition dilated cardiomyopathy (DCM), paving the way for more accurate diagnosis. By sequencing the gene encoding the muscle ...

In the past 40 years, researchers have explored the role of another filament: titin. Its emerging role in muscle function, unwinding during muscle relaxation and folding during contraction, suggests ...

K nowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...