There is an altered T-cell population in SSc patients, with an increased expression of Th2 and Th17 T cells and an altered phenotype in Treg cells. Epigenetic modification of the CD70 and CD40 ...

Disrupting CD154–CD40 interaction using monoclonal antibody against CD154 in vivo permits almost-indefinite kidney graft acceptance in nonhuman primates, thus moving this approach one step ...

1 Th1 cells primarily produce interferon (IFN)-g and interleukin (IL)-2, whereas Th2 cells produce IL-4, IL-5, IL-6, IL-10, and IL-13. The two helper T cell classes also differ by the type of immune ...

In June 23 Lancet, Richard Phipps and colleagues from University of Rochester Cancer Center, Rochester, New York, suggest that these febrile responses could be due to the release of CD40 ligand from ...

Allergen-specific immunotherapy involves researching adjuvants in order to modulate allergen-specific (known as Th2) immune ...