A team led by surgeon-scientist Dr. Vinod Balachandran identified the molecular pathway involved in the formation of tertiary lymphoid structures ... suggesting that the cytokine may play an ...
They discovered that a cell-signaling molecule (or cytokine) called interleukin-33 (IL-33) caused ILC2s and T cells to expand in tumors, which in turn had an anti-cancer effect in mice.
The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected in various types of cancer ...
A team led by surgeon-scientist Dr. Vinod Balachandran identified the molecular pathway involved in the formation of tertiary lymphoid structures. Therapeutically targeting this pathway could ...
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Cancer researchers shed light on how immune cell clusters formThe cytokine IL-33 and ILC2 immune cells ... More information: Masataka Amisaki et al, IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer, Nature (2025).
A team led by surgeon-scientist Dr. Vinod Balachandran identified the molecular pathway involved in the formation of tertiary lymphoid structures ... suggesting that the cytokine may play an important ...
TLSs are highly organized structures that typically appear as clusters of B-cells containing FDCs. These clusters are then surrounded by T-cells and HEVs as shown schematically in Figure 1.
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