Knight says that the method of transmission that Collinge identified is “extremely unusual,” and there’s no evidence that Alzheimer’s can spread through medical procedures used today. He also conceded ...

Hyperphosphorylated tau can impair synaptic function. The same kind of prion-like seeding and spreading may be how that pathological tau propagates into the neocortex in Alzheimer's disease.

The findings placed V337M/R406W-tau cases alongside AD, PART, FBD, and FDD in the top branch of the tauopathy tree (image above). Gerstmann-Sträussler-Scheinker disease and prion protein cerebral ...

In some circumstances Aβ oligomers can become misfolded into prion-like species that are directly neurotoxic, propagate by causing new monomers to take on the same toxic form, and lead to tau ...

These hallmark pathological structures are composed of misfolded tau proteins double labeled by a monoclonal antibody and a fluorescent small-molecule amyloid-binding probe. Unaffected cells ...