The specific tau isoforms, such as 3-repeat (3R) and 4-repeat (4R) isoforms, and the distinct conformational strains that misfolded tau can adopt are determinants of the molecular and clinical ...

In the adult human brain, tau exists in six isoforms, each with unique structural properties. These isoforms are produced through alternative splicing of the MAPT gene, with variations affecting ...

In the human brain, tau is found in six different isoforms, each with a molecular weight ranging from 48,000 to 67,000 daltons. Patients with neurodegenerative diseases and severe head traumas are ...

Intracellular tau aggregates are constituted by different isoforms and undergo multiple post-translational modifications leading to heterogenous ultrastructural conformations. Not only are they ...

These transgenic mice overexpress human tau, specifically the 4R/2N isoform, bearing the P301L mutation under the control of the neuron-specific murine Thy1 promoter (Terwel et al., 2005). The ...

Of the two, p-Tau has emerged as the more specific and robust biomarker — at least in blood samples. Although the ratio of the two isoforms of amyloid-Beta (aB42/40) changes significantly in CSF ...

including different isoforms and phosphorylation states of tau. After the fast and high-plex data acquired with GeoMx DSP, Orr’s team selected 68 biomarkers for single-cell spatial analysis with ...