Discussion within the report delves into the potential mechanisms by which COVID-19 vaccines could trigger TTP, focusing on the autoimmune response that may cross-react with ADAMTS13, leading to ...

A recombinant replacement for the ADAMTS13 protein (Adzynma) missing in congenital thrombotic thrombocytopenic purpura (TTP) restored levels and reduced acute TTP events, according to interim ...

“When these long VWF multimers are not cleaved by ADAMTS13, VWF-platelet aggregation occurs, leading to TTP,” says Karen Vanhoorelbeke, a biochemist at the University of Leuven (KU Leuven), Belgiu ...

Most individuals who have predominantly neurological symptoms and a clinical diagnosis of TTP have either a genetic or an acquired deficiency in ADAMTS13, a plasma protease that cleaves von ...

cTTP is a subtype of thrombotic thrombocytopenic purpura (TTP), a rare and life ... and is caused by a deficiency in the ADAMTS13 protease enzyme. It is estimated there are fewer than 1,000 ...