One genetic mutation may transform the way we treat rheumatoid arthritis, a disease that will affect an estimated one percent of the world. York University researchers have identified a mutation in ...

Figure 1: Activated T cells from human subjects with an RA-associated SNP express less TRAF1 and produce less cytokines. Figure 2: Monocytes from human PBMCs with an RA-associated SNP express ...

Research reveals how a specific mutation in a protein called TRAF1 can shut down an overactive immune response, dramatically reducing inflammation in mice. This discovery could pave the way for a ...

Here we report that tumour necrosis factor receptor-associated factor 1 (TRAF1) expression is markedly induced in wild-type mice 6 h after stroke onset. Using genetic approaches, we demonstrate ...

Toronto, Feb. 27, 2025 (GLOBE NEWSWIRE) — Research led by York University’s Faculty of Health reveals how a specific mutation in a protein called TRAF1 can shut down an overactive immune ...