Among those genes, TP53 (encoding the p53 protein) has been identified as the most frequently mutated gene that causes cancer ...

14 In the excitement of discovery that sparked new explanations for cancer, scientists had quickly fit a label onto p53, but an oversight soon came to light. All the various tp53 and Trp53 clones used ...

In many cancer types, the TP53 gene is often mutated or deleted, which inactivates the tumour suppression activity of the p53 protein. However, loss of p53 tumour-suppressor activity can also ...

Mindrank Therapeutics (Suzhou) New Drug Research & Development Co. Ltd. has disclosed cellular tumor antigen p53 (TP53) (Y220C mutant) stabilizers reported to be useful for the treatment of cancer.