IO Biotech (Nasdaq: IOBT), a clinical-stage biopharmaceutical company developing novel, immune-modulatory, off-the-shelf therapeutic cancer vaccines, today announced the presentation of new ...

Cardiac fibroblasts (CF) can become activated and produce excessive extracellular matrix, contributing to fibrotic remodeling ...

Among these factors, the transforming growth factor (TGF)-β family is important in both lineage selection and progression of differentiation of most, if not all, cell and tissue types.

TGF-β plays a critical role in liver homeostasis and is considered a key driver of liver fibrosis. When TGF-β is converted from its biologically inactive form (LTGF-β) to its active form (TGF ...

A new study published in The New England Journal of Medicine showed that for high-risk patients with pulmonary arterial ...

A new review published in Genes & Diseases highlights the transformative role of microRNAs (miRNAs) in regulating and ...

More information: Jaclynn A. Meshanni et al, Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ...

The goal of the study was to confirm whether modified NK cells had the capacity to overcome the negative effects of the TGF-β and Activin A molecules in preclinical models of HER2 positive breast ...

Future Virology. 2013;8(11):1127-1134. Many cytokines (e.g., IL-1, IL-8, TGF-β and TNF), chemokines (e.g., MCP-1, MIP-1a and RANTES), growth factors (e.g., EGF ...

NOTCH signaling influences these traits through interactions with other pathways like TGF-β, WNT, and hypoxia signaling. The canonical NOTCH pathway maintains resistant cell populations ...