"By eliminating SMAD4, we make these cells resistant to the TGF-β's inhibition ... including those expressing chimeric antigen receptors (CAR), which allows recognition of specific antigens ...

Expression of the cell cycle inhibitor p15 INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b ...