TFIIH is a multiprotein complex that is involved in various cellular processes, including nucleotide excision repair (NER) and transcription, revealing the tight molecular connections between ...

Figure 1: TFIIH mediates cdk8-dependent repression by NAT. Figure 2: Properties of the Mediator-like complex, devoid of cdk8. Figure 3: cdk8/cyclin C phosphorylates the cyclin H subunit of TFIIH.

Completing a years-long collaboration with the Ranish and Kaplan labs, we publish an article in JBC that identifies key residues within the p52 subunit that control TFIIH function at transcription ...

The key steps in the NER reaction include damage recognition, strand separation by the molecular motor TFIIH, and excision of about 30 nucleotides by the nucleases XPG and XPF to remove the damage ...

The Pre-Initiation Complex (PIC), which consists of Mediator, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA polymerase II (pol II), governs the expression of all protein-coding and most non-coding ...

Author contributions: P.D.L., L.M.M.J., J.A., P.L., and J.G.O. designed research; P.D.L., L.M.M.J., C.M., C.L., E.M., A.F.-T., J.A., P.L., and J.G.O. performed ...