To enhance CAR T therapies, scientists are actively studying TCR signaling and T-cell exhaustion mechanisms to improve CAR T ...

9,10 (7) A T cell antigen coupler (TAC) and a TCR fusion construct (TRuC) also engage endogenous TCR signaling, but, similar to a CAR, they bind to tumor antigens. This can increase receptor ...

The researchers suggest that this pattern arises because Lck molecules, which help transmit signals between TCR and CD45 ... complete view of early T-cell signaling, with potential applications ...

A pioneering study uncovers crucial immune dynamics in hepatitis B, offering new insights into how immune responses evolve ...