The diversity of the TCR repertoire, however, means that sequencing is technically challenging, particularly for samples with low-quality, degraded nucleic acids. Current methods have significant ...

Investigators assessed vaccine-induced T cell responses using ex vivo IFNγ ELISpot assays, T cell receptor (TCR) sequencing, and longitudinal blood and tissue analyses over a median follow-up of ...

"Overall, ATLAS-seq improves TCR screening to more effectively identify ... determined their unique TCR sequences using single-cell sequencing. "We envision that ATLAS-seq can play a pivotal ...

Paired BCR and TCR data were available for 542 individuals ... Results indicate that immune receptor sequencing can potentially serve as a versatile diagnostic tool for a range of infections ...